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Research supporting the efficacy of Canker Care+TM
1) In this study, topical licorice (DGL) dramatically improved aphthous ulcers within a day, and eliminated them within three days. Deglycyrrhizinated liquorice in aphthous ulcers.
Twenty patients with aphthous ulcers were advised deglycyrrhizinated liquorice (DGL) mouth wash and were followed for two weeks. Fifteen patients experienced 50-75% improvement within one day followed by complete healing of the ulcers by third day. 2) This study presents clinical research that topical propolis can help with gingivitis, and canker sores. Preliminary study of the effects of propolis in the treatment of chronic gingivitis and oral ulceration Martinez Silveira G, Gou Godoy A, Ona Torriente R, Palmer Ortiz MC, Falcon Cuellar MA.
Since many years ago are known curative effects of propolis on different lesions due, mainly, to more than 30 biologically active elements isolated from it. It is a wordly accepted opinion that propolis is one of the most useful substances elaborated by bees. Despite it, its use in our country is relatively recent. Several investigators, specially in Matanzas, study curative effects of propolis in the field of human and animal medicine. In other countries it has been used in stomalogy, but we have no knowledge about its therapeutical effects in the periodontal disease or its effectiveness in oral ulcers. Therefore, a therapeutical form has been elaborated, which is provisionally called Propolan, for the treatment of two entities: chronic gingivitis and stomatitis of different etiology. The clinical cases supporting effectiveness found with the treatment applied in our setting are presented. 3) In this study, and aloe vera "patch" showed efficacy in eliminating canker sore discomfort.
BACKGROUND: To evaluate the efficacy of a new bioadhesive patch, Aloe vera hydrogel, for the treatment of aphthous stomatitis. METHODS: An open, not controlled study was performed in 31 pediatric out-patients, aged 6-14 years, affected by mouth ulcers were enrolled consecutively in the 3 Gps Depts+ of San Marino Republic. For each case, data on case history and clinical profile, patterns of the lesion, presence of spontaneous or provoked pain were collected at baseline, and a bioadhesive patch ("Alovex patch") was administered on the basis of a daily regimen of < or = 3 patches for 4 days. Data on modification of the above-mentioned parameters, with patients and physicians opinion on the therapeutical efficacy, were collected during a control visit (4 days later). Moreover, by means of a daily diary, patients recorded information on the course of the symptoms during the 4 days and were also asked to compare the current treatment with other previous therapies. RESULTS: At the control visit 77% of the patients have shown a marked resolution of spontaneous pain, while in the other patients, pain was significantly decreased to a "mild" or "moderate" level. No one child declared to suffer from severe pain. Also provoked pain resulted to be significantly decreased after treatment Global efficacy was judged positively, being the therapeutical effect in more than 80% of cases "evident or of absolute improvement" both by physicians and patients opinion. A positive improvement of symptomatology started within the 2nd day of treatment in 74% of the patients. The compliance (adhesivity, acceptability and palatability) of the formulation was judged largely favourable in more than 90% of the patients. CONCLUSIONS: The results of this study underline the good efficacy and compliance of the patch for the treatment of the aphtous stomatitis; also the limit of topical available therapies, linked to the "contact time", to develop their therapeutical action, seems not to be evinced on the basis of this study, so the application of this patch seems to be more easy and beneficial. 4) In this study, a relationship is drawn between Vitamin B12 deficiency and aphthous ulceration. Vitamin B12 is absorbed through the mouth into the system. Aphthous ulcers and vitamin B12 deficiency.
Aphthous ulcers of the oral cavity are frequently encountered in general practice. Although the exact pathophysiology remains obscure, many factors can contribute to the pathogenesis of these lesions, such as immunological factors, local trauma, smoking, stress, hormonal state, family history, food hypersensitivity, and infection. We describe three patients in whom a clear relationship appeared to exist between recurrent aphthous ulcers and a deficiency of vitamin B12. It is concluded that in all patients with recurrent aphthous ulceration, deficiency of vitamin B12 should be considered. 5) A correlation is drawn between B12 deficiency and canker sores. Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis.
BACKGROUND: The exact aetiology of recurrent aphthous stomatitis (RAS) is still unknown, but different predisposing factors, including iron, vitamin B12 and folic acid deficiencies, have been proposed. MATERIAL AND METHODS: Serum iron, ferritin, folic acid and vitamin B12 levels were investigated in 35 patients with RAS and in 26 healthy controls. RESULTS: Vitamin B12 levels were found significantly lower in subjects with RAS than in controls. No significant differences were found in other parameters. CONCLUSION: We concluded that vitamin B 12 deficiency may be an aetiological factor in recurrent aphthous stomatitis. View products now - Canker Sore |