Cold Sore Healing Time and Severity of Symptoms Significantly Reduced With LIP CLEAR^® Lysine + Topical Ointment

Cold sore sufferers using LIP CLEAR Lysine + topical ointment healed more quickly and experienced significantly reduced symptoms according to a new study from Southern California University of Health Sciences. That's good news for the 60 million people with active cold sores.

"The formula reduced the duration of cold sore symptoms by 50% or more when compared to untreated cold sore data." said Betsy Singh, PhD, the University's Dean of Research. The median healing time was 4.0 days - 1/2 to 1 full day shorter than in the studies on the leading prescription and OTC brands which cost 3 to 5 times more.

The study results were presented by Dr. Singh and her colleagues in January at the Scripps Institute for Integrative Medicine conference titled Natural Supplements in Evidence-Based Practice: A Clinical and Research Update. The meeting was co-hosted by University of California San Diego Continuing Medical Education. The study was co-authored by Jay Udani, MD, Medical Director of the Integrative Medicine Program at Northridge Hospital, Assistant Clinical Professor at the UCLA / Geffen School of Medicine and Adjunct Professor of Research at SCU.

The study, Safety and Effectiveness of a Lysine Based Product on the Treatment of Facial and Circumoral Herpes, also showed that within three days, the LIP CLEAR either completely eliminated or dramatically reduced cold sore symptoms, including tingling, burning, itching, tenderness, prickling, soreness and blistering. In addition, a remarkable 40% of the participants had full cure by end of the third day. No adverse effects were reported.

The LIP CLEAR Lysine + formula includes a proprietary blend of L-Lysine, natural zinc oxide, Vitamins A, D and E, extracts of goldenseal, propolis, calendula, echinacea; cajeput and tea tree oil, and gum benzoin tincture, honey and lithium carbonate in a base of olive oil and yellow beeswax.

According to the researchers, participants commented that the formula provided a superior experience compared to other formulas; it was invisible, did not burn when applied, and provided immediate relief.

This open label outcome study measured time to full cure as well as ten common symptoms. Full cure referred to the complete disappearance of the lesion, not merely crusting, the end point in most studies (crusting may take 2 to 7 more days to disappear). The ten factors for monitoring the sores were: tingling, itching, burning, tenderness, prickling, soreness, bump/swelling, small blister(s), oozing blister(s), and crusting. 120 subjects pre-enrolled and 30 subjects, half male/female, 28 to 65, participated. All subjects were experienced cold sores sufferers and were familiar with other treatments and their efficacy.

Cold sores are small blisters that form around the mouth that are clear and filled with fluid. Cold sores are caused by the herpes simplex virus which lives inside nerve tissue. It is estimated that 80% of the population carry the virus and 60 million people have outbreaks once or more per year. Cold sores are also known as Herpes Simplex or HSV1 (not the same as genital herpes) and may be referred to as fever blisters. Cold sores can be triggered by sunlight, fever, illness, stress, arginine rich foods such as chocolate, food allergies or hormonal changes. Early symptoms of an outbreak are itching, tingling or a burning sensation. Cold sores are contagious and can be spread by kissing or sharing eating utensils, toothbrushes, towels or razors.

The study was authored by Betsy B. Singh, Ph.D., Jay Udani, M.D., Sivarama Prasad Vinjamury, M.D. (Ayurveda), Claudia Der-Martirosian, PhD., Sonal Gandhi, M.D., Rahelea Khorsan, M.A., Dinesh Nanjegowda, Ph.D., and Vijay Singh, B.A.

The Scripps Center for Integrative Medicine is a part of the Scripps Clinic and Research Foundation, La Jolla, California.

BACKGROUND INFO

Study leader Betsy Singh, PhD is the Dean of Research at the Southern California University of Health Sciences in Whittier, California. She has over 20 years experience as a teacher and researcher with various universities in both academic and medical departments, including her former position as Director of Research, Program in Complementary Medicine, University of Maryland School of Medicine, an NIH-funded site. Formerly, she was a Director of EMP:rs, an ORU for the UMD School of Medicine where her research group included to 80 persons including field staff in order to participate in dozens of research projects per annum. She is also chair of the Research Oversite Committee for the government funded project to assess the effect of vitamin and mineral supplementation for at-risk children. She is affiliated with the Center for Complementary Health Care and a member of the Geriatrics Program, University of California, Irvine. She serves as an advisor to RAND for the AHQR sponsored Evidence-Based practice Center for Complementary and Alternative Medicine She has been PI, Co-PI, or methodologist on a variety of grants in both complementary and conventional medicine.

Dr. Singh served on CRP Special Emphasis Panel, and serves on dissertation committees on a variety of medical topics. Dr. Singh won the Research Excellence Award (Sept. 2002) and the Blood of the Turnip Award (Sept. 2002) for work above and beyond the call of duty. She is an editor for Alternative Therapies in Health and Medicine (5\1\98 -1/1/03), formerly on the advisory board (7\97-5\1\98) returned as of 1/1/03, and reviews for other journals as well. She also serves on the scientific review committee for the Consortial Center for Chiropractic Research [CCCR] (5/98) funded by the NCCAM/NIH. She is a member of the Homeopathic Pharmeacopia of the U.S. (HPCUS), an oversight committee for Homeopathy. She is affiliated with the Center for Complementary Health Care and a member of the Geriatrics Program, University of California, Irvine. She serves as an advisor to RAND for the AHQR sponsored Evidence-Based practice Center for Complementary and Alternative Medicine She has been PI, Co-PI, or methodologist on a variety of grants in both complementary and conventional medicine.

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